Monthly Archives: January 2010

Multifunctional Nanoparticles Application for drug delivery applications

Multifunctional Nanoparticles Application

Multifunctional Nanoparticles Application: major aim of medicine has long been the early and accurate diagnosis of clinical conditions, providing an efficient treatment without secondary effects. With the emergence of nanotechnology, the achievement of this goal seems closer than ever. To this end, the development of novel materials and devices operating at the nanoscale range, such as nanoparticles, provides new and powerful tools for imaging, diagnosis and therapy. This review focuses on the significant improvements in performance that nanoparticles offer compared with existing technologies r elevant to medicine. Specifically, we address the design of multifunctional nanoparticles as an alternative system for drug and gene delivery, which has great potential for therapy in areas, such as cancer and neuropathologies. Moreover, we discuss the controversy generated by the possible toxic health effects of nanoparticles.

Multifunctional Nanoparticles Application

Multifunctional Nanoparticles Application

Multifunctional Nanoparticles Application: Nanoparticles are constructs that possess unique physical and chemical properties associated with their being of 1– 100 nm in size. The general characteristics and composition of nanoparticles are described in Box 1 and are illustrated in Figure 1. Nanometre-sized particles are in the same range of dimension as antibodies, membrane receptors, nucleic acids and proteins, among other biomolecules. These biomimetic features, together with their high surface:volume ratio and the possibility of modulating their properties, make nanoparticles powerful tools for imaging, diagnosis and therapy. Thus, nanoparticles offer significant improvements in performance compared with existing technologies. As a result, commercialisation of nanoparticle-based therapeutics is gaining momentum, with an increasing number of available products on the market. Table 1 gives examples of commercial nanoparticle-based products. Other issues related to nanoparticle technology, such as biomolecule–nanoparticle hybrid systems and their use towards medical diagnostics and therapeutics, have been reviewed elsewhere.

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Multifunctional Nanoparticles Application

Multifunctional Nanoparticles Application

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Nano silver drug delivery for cancer Treatment

Nano silver drug delivery for cancer Treatment

Based on the future drug delivery vehicle, a drug in nanoformulation based on targeted drug delivery for effective treatment of cancer is developed. The drug is a Nano formulation consisting of a Nanocarrier, Cancer specific receptor or general receptor, Sensing material to identify if the cell is normal, malignant or benign, Substance to indicate the amount of uptake of the nanomaterial by the cell for the staging of cancer, a drug wrapped in a charged molecule, stabilizing and binding agent.When an external electrical potential is applied to the solution containing

Nano silver drug delivery

Nano silver drug delivery

The mixture of stabilizing or binding agent, drug, cancer specific receptor or general receptor, sensing material, the binding agent loses its negative charge, which causes the nano formulation to disintegrate, releasing the drugs. The amount of drug delivered and the timing of the dose can be precisely controlled by turning the voltage on and off. The electrical signal can be remotely administered (for example, by a physician) using radio signals or other techniques that have already been developed for other biomedical devices. The formulation can carry discrete packets of drugs that can be released separately, which could be especially beneficial for chemotherapy.

Nano silver drug delivery is a most promising field for generating new applications in medicine. However, only few nanoproducts are currently in use for medical purposes. Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients.Nanotechnology is the design, characterization, production and applications of structures, devices and systems by controlling shape and size at the nanometer scale. Nanometer-sized particles offer novel structural, optical and electronic properties that are not attainable with individual molecules or bulk solids.

Nano silver based targeted drug delivery for treatment of cancer

Nano silver drug delivery  are of great scientific interest as they are effectively a bridge between bulk materials and atomic or molecular structure. Advances in nanomedicine can be made by engineering nanoparticles that are capable of targeted delivery of drugs. Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans and animals.Drug delivery technologies modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance.Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation Several therapeutic nanocarriers have been approved for clinical use. Nanocarriers can offer many advantages over free drugs.

Nano silver drug delivery there are only a few clinically approved nanocarriers that incorporate molecules to selectively bind and target cancer cells. In recent years, metallic nanoparticles have drawn a lot of attention due to their unusual physical and chemical properties, which largely differ from their bulk properties. Among all metals, silver has the highest electrical and thermal conductivity. Our present work proposes a drug in nanoformulationbased on targeted drug delivery for effective treatment of cancer. The nanoformulation has a Nanocarrier Conjugation of Nano particles with PEG (Pegylation favor the pharmacokinetics of the these nano formulations prolonging the circulation periods that grant a proper time frame for the nano particles to be accumulated in the tumor micro environment although PEG is the most effective method to reduce protein adsorption invivo and to avoid the RES system clearance). Cancer specific receptor or general receptor.

Nano silver drug delivery  material for to identify if the cell is normal, malignant or benign. Substance to indicate the amount of uptake of the nanomaterial by the cell for stagingthe cancer.f.A drug, pemetrexed which is an FDA approved drug in the treatment of malignant Pleural Mesothelioma, a type of tumor of the lining of the lung. In combination with other drugswhose disease is unrespectable orwho are otherwise candidates for curative surgery. A stabilizing and binding agent.

We invite you to contact us for Nano silver drug delivery  information about our company and our capabilities. If you want to buy nanomaterials or discuss Oxide Nanoparticles,you can mail us at sales@nanoshel.com

Nano silver drug delivery

Nano silver drug delivery

Contact Us for Nano silver drug delivery
From us, you can easily purchase nanomaterials at great prices. Place online order and we will dispatch your order through DHL, FedEx, UPS. You can also request for a quote by mailing us at sales@nanoshel.com Contact: +1 302 268 6163 (US and Europe), Contact: +91-9779550077 (India). We invite you to contact us for further information about our company and our capabilities. At Nanoshel, we could be glad to be of service to you. We look forward to your suggestions and feedback.

Silver nanoparticles Properties

 Silver nanoparticles Properties

Silver nanoparticles Properties has many medical applications including diagnosis, treatment, drug delivery, coating tools and medical devices. Nanosilver is used for coating medical tools and materials used in the areas of surgery, anesthesiology, cardiology and urology . It is also incorporated in wound dressings, diabetic socks, scaffolds, sterilization materials in hospitals, medical textiles, medical catheters and contraceptive devices. Nanosilver is used in orthopedics in areas such as additives in bone cement, coating of implants for joint replacement and bone prostheses

Silver nanoparticles Properties

Silver nanoparticles Properties

 

Silver nanoparticles Properties is used in dentistry for making artificial teeth and in eye care for coating contact lenses . Advanced silver nanotechnologies are used to improve battery performance in next-generation active implantable medical devices. The use of nanosilver in combination with vanadium oxide in battery cell. These factors affect the chemical reactivity of materials as well as their mechanical, optical, electric, and magnetic properties. Nanosilver has chemical and biological properties that are appealing to the consumer products, food technology, textiles/fabrics, and medical industries. Nanosilver also has unique optical and physical properties that are not present in bulk silver, and which are claimed to have great potential for medical applications.

Silver nanoparticles Properties Antibacterial properties: Nanosilver is an effective killing agent against a broad spectrum of Gram-negative and Grampositive bacteria , including antibiotic-resistant strains (Percival et al., 2007; Wright et al., 1998). Gram-negative bacteria include genera such as Acinetobacter, Escherichia, Pseudomonas, Salmonella, and Vibrio. Acinetobacter species are associated with nosocomial infections, , infections that are the result of treatment in a hospital or a healthcare service unit, but secondary to the patient’s original condition. Gram-positive bacteria include many well-known genera such as Bacillus, Clostridium, Enterococcus, Listeria, Staphylococcus, and Streptococcus. Antibiotic-resistant bacteria include strains such as methicillin-resistant and vancomycin-resistant Staphylococcus aureus, and Enterococcus faecium. Silver nanoparticles (diameter 5-32 nm, average diameter 22.5 nm) enhance the antibacterial activity of various antibiotics . The antibacterial activities of penicillin G, amoxicillin, erythromycin, clindamycin, and vancomycin against Staphylococcus aureus and Escherichia coli increase in the presence of silver nanoparticles (diameter 1-450 nm) antimicrobial activity of silver nanoparticles has been reported with Gram-negative bacteria. Small nanoparticles with a large surface area to volume ratio provide a more efficient means for antibacterial activity even at very low concentration.

Silver nanoparticles Properties Antibacterial mode of action: Bacteria have different membrane structures, which are the bases of their general classification as Gram-positive or Gram-negative. Structural differences reside in the organization of the key component of the cell wall, peptidoglycan, which is located immediately outside the cytoplasmic membrane. The cell wall of Gram-positive bacteria contains a peptidoglycan layer that is ~30 nm thick. Unlike the Gram-positive cell wall, the Gram-negative cell wall has only a thin peptidoglycan layer that is ~2-3 nm thick. In addition to the peptidoglycan layer, the Gramnegative cell wall also contains an additional outer membrane composed of phospholipids and lipopolysaccharides, which face into the external environment.

Silver nanoparticles Properties: Nanosilver is an effective, fast-acting fungicide against a broad spectrum of common fungi including genera such as Aspergillus, Candida, and Saccharomyces . The exact mechanisms of action of silver nanoparticles against fungi are still not clear, but mechanisms similar to that of the antibacterial actions have been proposed for fungi (Wright etal., 1999). Silver nanoparticles (diameter 13.5 ± 2.6 nm) are effective against yeast isolated from bovine mastitis

Antiviral properties: Silver nanoparticles Properties (diameter 5-20 nm, average diameter ~10 nm) inhibit HIV-1 virus replication. Gold nanoparticles (average diameter ~10 nm) showed relatively low anti HIV-1 activity (6-20%) when compared to silver nanoparticles (98%). Sizedependent antiviral activity of silver nanoparticles has been shown with HIV-1 virus . Interaction of silver nanoparticles with HIV-1 was exclusively within the range of 1-10 nm.

Silver nanoparticles Properties: Nanosilver dressings as well as nanosilver-derived solutions proved to have anti-inflammatory activity . In animal models, nanosilver alters the expression of matrix metallo-proteinases (proteolytic enzymes that are important in various inflammatory and repair processes) , suppresses the expression of tumor necrosis factor (TNF)- , interleukin (IL)-12, and IL-1 , and induces apoptosis of inflammatory cells (Bhol & Schechter, 2005, 2007). Silver nanoparticles (diameter 14 ± 9.8 nm) modulate cytokines involved in wound healing (Tian et al., 2007). The results indicate the possibility of achieving scar-less wound healing even though further studies using other animal models are required to confirm this.

Anti-glycoprotein film properties: Glycoproteins are proteins that contain oligosaccharide chains that are covalently attached to polypeptide side-chains. These proteins are important for normal immune system function such as white blood cell recognition, and often play a role in cell-cell interactions. Examples of glycoproteins in the immune system include molecules such as antibodies that interact directly with antigens. In the case of impregnation of medical-grade silicone with silver nanoparticles (diameter 10-100 nm) there is both a depot effect and a diffusion pressure available to equilibrate the silver concentration and to push silver through the glycoprotein conditioning film . This unexpected finding has obvious clinical implications, because silver is known to have a high avidity to protein and the presence of a lycoprotein film has been assumed to inactivate any silver ions released. Surfaces of implanted devices immediately and rapidly become coated with patient-derived glycoproteins from tissue and blood plasma . Once protein adhesion has occurred, proliferation leads to the development of a biofilm which is insusceptible to most therapeutic agents.

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Silver nanoparticles Properties

Silver nanoparticles Properties

Contact Us for Silver nanoparticles Properties
From us, you can easily purchase nanomaterials at great prices. Place online order and we will dispatch your order through DHL, FedEx, UPS. You can also request for a quote by mailing us at sales@nanoshel.com Contact: +1 302 268 6163 (US and Europe), Contact: +91-9779550077 (India). We invite you to contact us for further information about our company and our capabilities. At Nanoshel, we could be glad to be of service to you. We look forward to your suggestions and feedback.