Multifunctional Nanoparticles Application
Multifunctional Nanoparticles Application: major aim of medicine has long been the early and accurate diagnosis of clinical conditions, providing an efficient treatment without secondary effects. With the emergence of nanotechnology, the achievement of this goal seems closer than ever. To this end, the development of novel materials and devices operating at the nanoscale range, such as nanoparticles, provides new and powerful tools for imaging, diagnosis and therapy. This review focuses on the significant improvements in performance that nanoparticles offer compared with existing technologies r elevant to medicine. Specifically, we address the design of multifunctional nanoparticles as an alternative system for drug and gene delivery, which has great potential for therapy in areas, such as cancer and neuropathologies. Moreover, we discuss the controversy generated by the possible toxic health effects of nanoparticles.
Multifunctional Nanoparticles Application: Nanoparticles are constructs that possess unique physical and chemical properties associated with their being of 1– 100 nm in size. The general characteristics and composition of nanoparticles are described in Box 1 and are illustrated in Figure 1. Nanometre-sized particles are in the same range of dimension as antibodies, membrane receptors, nucleic acids and proteins, among other biomolecules. These biomimetic features, together with their high surface:volume ratio and the possibility of modulating their properties, make nanoparticles powerful tools for imaging, diagnosis and therapy. Thus, nanoparticles offer significant improvements in performance compared with existing technologies. As a result, commercialisation of nanoparticle-based therapeutics is gaining momentum, with an increasing number of available products on the market. Table 1 gives examples of commercial nanoparticle-based products. Other issues related to nanoparticle technology, such as biomolecule–nanoparticle hybrid systems and their use towards medical diagnostics and therapeutics, have been reviewed elsewhere.
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