Custom Synthesis : Custom Manufacturing

Custom Synthesis

Custom Synthesis: NANOSHEL’s Scientists are skilled in the latest methods in synthetic organic chemistry to work closely with clients.

Custom Synthesis: We ensure high quality standard and on time complete delivery. NANOSHEL has an expertise in the design and preparation of multi-step targets on scales ranging from milligrams to kilograms. Our scientists of R&D team are well trained to focus efforts to evaluate the synthesis. Normally, your inquiries will be addressed within 48 hours upon receipt of request. We will offer a ballpark price and a lead time for the project in a timely manner. NANOSHEL honors its quoted price even when the project might require more work than anticipated. We won’t charge our clients for failed synthesis.

Custom SynthesisCustom Synthesis NANOSHEL offers the design and synthesis of multipurpose screening compounds to meet your exact screening requirements. Specify compounds, quantities, format (dry/solid or DMSO) and the tube, vial or plate required to complement your compound handling system. We also offer one of the most powerful screening platforms in the industry with over 850,000 unique chemical compounds and approximately 100,000 probes from natural sources to suit different in capacity and assays. Each library may be screened individually or in combination with other libraries, allowing a tailored approach to HTS project requirements and the greatest coverage of chemical space to maximize the chance of finding hits. Chemical compounds in our library collections are available for re-supply from our USA stock.

Custom Synthesis Customers are also welcome to provide literature methods or their own synthetic routes in which all relevant information such as reaction time, solvent, temperature, analytic data, purification method, yield, etc. are detailed. In the case where there is a lack of technical data, we are still capable of providing a rough estimate upon a careful review of the research paper. We work in state-of-the-art laboratories, equipped with the latest process and analytic instruments, NANOSHEL scientists have good experience and infrastructure to make your project a success story.

Custom Synthesis

Custom Synthesis Process

Design of new syntheses

  • Chiral synthesis and resolution
  • Scale-up of existing literatures or customer supplied synthesis, custom manufacturing of chemicals in bulk quantities
  • Modification or replacement of poorly performing steps in a synthesis
  • Design and synthesis of multipurpose screening compounds
  • Molecules include but not limited to screening compounds, starting materials, building blocks, intermediates or derivatives of lead compounds
  • Development and validation of analytical methods
  • X-ray crystallography service

Nanoshel Conjugates:

Nanotechnology suggests unique approaches to detect and regulate diversity of biomedical processes that take place at nanometer scale, and is expected to have a fundamental effect on biology and medicine. Nanoshel gives the Useful features which can be incorporated into nanoparticles for manipulation or detection of biological structures and events.

Custom Synthesis

Biomedics – Drug Conjugation

Different characteristics of nanoparticles such as size, shape and surface charge have all been shown to strongly influence therapeutic and diagnostic efficiency by changing cell uptake and functional surface area. Nanoparticles are defined as particles between 1 and 100 nm that have a range of unique properties including surface chemistry, size & shape dependent, electronic and optical properties that support a variety of applications containing drug and gen delivery, bioimaging, vaccine development, biosensors, and therapies.

Custom Synthesis

Conjugates-Sem

Nanoshel Bioconjugation simply involves the bond of biomolecules to nanoparticles by chemical or biological means, which render them ideal for clinical applications; it includes the conjugation of biologically active molecules to nanoparticles. The outcome is the combinations of beneficial properties.

Nanoshel provide the custom synthesis of the conjugation of different functionalized groups to nanoparticles is necessary for their stability, functionality, and biocompatibility and develops their application fields, and provides them with novel and improved properties. Nanoshel attached a range of functionalized groups to the nanoparticles including low molecular weight ligands, peptides, proteins, polysaccharides, polyunsaturated and saturated fatty acids, DNA, plasmids, and RNA.

Custom Synthesis: Nanoparticles have been often studied due to their unique surface, chemical inertness, high electron density, and strong optical absorption. In recent decades, Nanoshel nanoparticles have been applied in genomics, clinical chemistry, vaccine development, immunoassay, biosensor, diagnosis, and microorganism’s control, cancer-cell imaging, and drug delivery. In addition, the Nanoparticles conjugated by prostate specific membrane antigen (PSMA) RNA aptamer after loading of doxorubicin can be useful as mtherapeutic agents for diagnosis and treating of prostate cancer.

It has also been reported that it is possible to control the interactions of NPs with cell membranes in order to improve their cellular uptake while minimizing their toxicity by rigid change of their surface charges densities. NPs conjugated by dn GE GhbioEa have also been used as effective agents for plasmonic photo thermal therapy. To develop observation of NPs based therapeutics or diagnostic agents, the surface decoration are principally esteemed necessary. Surface decoration or conjugation is commonly used to improve drug loading, decrease Immunogenicity, decrease aggregation or increase stability, improve cellular uptake, actively target cancer cells, and tumors.

 

We would be glad to hear from you and we look forward to collaborating with you!

 


Contact Us:

Please feel free to send us your requirement about our products
sales@nanoshel.com
contact@nanoshel.com
+1 646 470 4911 (US)
+36 30 4750555 (EU)
+91-9779880077 (India)