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Process R&D

Process R&D: NANOSHEL begins with a thorough screening of the process parameters. Stress tests are also run to make sure that the reactions are controlled; for example, key impurities could be identified to determine if they have the potentiality to cause problems in the isolation of the final product. Efficiency of each operation is carefully evaluated to minimize the waste generation for the environmentally friendly synthesis. All the chemical operators in NANOSHEL undergo rigorous training and testing to ensure that safety procedures are both understood and followed.
NANOSHEL laboratories are well equipped for chiral resolution of compounds. Other services encompass chiral compounds synthesis and asymmetric catalysis synthesis. NANOSHEL offers the service of Scanning Electron Microscopy, a proven technique for determining the structure of materials, especially the configuration of nanomaterials. We help our customers surmount obstacles in their research projects by conducting Scanning Electron Microscopy, on samples prepared by the client or synthesized and characterized by us.

With support from our expert team of analysts, chemical engineers and QA professionals, NANOSHEL can develop scalable manufacturing processes efficiently to meet any need. We ensure that all the detailed data in every single step, such as time, temperature, purity and source of the starting material and solvent, purification method and storage condition is well recorded to make sure that all the steps are repeatable. NANOSHEL is expertise to provide safe, cost-effective process R&D.


A US government agency, the National Science Foundation defines three types of R&D.
  • Basic Research
  • When research aims to understand a subject matter more completely and build on the body of knowledge relating to it, then it falls in the basic research category. This research does not have much practical or commercial application. The findings of such research may often be of potential interest to a company
  • Applied Research
  • Applied research has more specific and directed objectives. This type of research aims to determine methods to address a specific customer/industry need or requirement. These investigations are all focused on specific commercial objectives regarding products or processes.
  • Development
  • Development is when findings of a research are utilized for the production of specific products including materials, systems and methods. Design and development of prototypes and processes are also part of this area. A vital differentiation at this point is between development and engineering or manufacturing. Development is research that generates requisite knowledge and designs for production and converts these into prototypes. Engineering is utilization of these plans and research to produce commercial products.


There are a number of terms that are often used interchangeably. Thought there is often overlap in all of these processes, there still remains a considerable difference in what they represent. This is why it is important to understand these differences
  • R&D
  • The creation of new body of knowledge about existing products or processes, or the creation of an entirely new product is called R&D. This is systematic creative work, and the resulting new knowledge is then used to formulate new materials or entire new products as well as to alter and improve existing ones
  • Innovation
  • Innovation includes either of two events or a combination of both of them. These are either the exploitation of a new market opportunity or the development and subsequent marketing of a technical invention. A technical invention with no demand will not be an innovation.
  • New Product Development
  • This is a management or business term where there is some change in the appearance, materials or marketing of a product but no new invention. It is basically the conversion of a market need or opportunity into a new product or a product upgrade
  • Design
  • When an idea is turned into information which can lead to a new product then it is called design. This term is interpreted differently from country to country and varies between analytical marketing approaches to a more creative process.
  • Product Design
  • Misleadingly thought of as the superficial appearance of a product, product design actually encompasses a lot more. It is a cross functional process that includes market research, technical research, design of a concept, prototype creation, final product creation and launch. Usually, this is the refinement of an existing product rather than a new product.


Evaluation and selection of routes for target molecules; Assessment of critical process parameters; Rapid screening of reactions conditions by utilizing parallel equipment; Perform reliable methods for in-process testing and analysis of intermediates and APIs; Development of continuous flow processes.


Optimization of reaction conditions to have more efficiency operations by classical methods or statistical design of experiments; Process improvement for cost reduction and throughput maximization.


Development of rapid scale-up of your Current Good Manufacturing Practice raw materials or process intermediates from the kilogram to metric tonne scale both in the Kilo-Lab and Pilot Plant


Safety and impurity management strategy; Hazard and process safety evaluations with tools including multiple RC-1 reaction calorimeters, a HEL Thermal Screening unit (TSU) and multiple differential scanning calorimeters

Technology support

Low temperature, high temperature and high pressure chemistry; Photochemistry; Numerous LC/MS (including UFLC/MS and UPLC/MS with PDA and ELSD detectors); HPLC, GC/MS, GC and Headspace-GC; Bruker NMR; Waters auto purification systems; Thar SFC (Analytical and Preparative); XRD, FT-IR; UV-Vis; IR; KF titrator, polarimeter; SEM, TEM, X-ray crystallography