Home » Doxorubicin Hydrochloride (C27H29NO11, Purity: 99.9%)

STIMULATES/ALUMINATES

Stock No. CAS MSDS Specification COA
NS6130-12-000069 25316-40-9 Specification pdf

Doxorubicin Hydrochloride (C27H29NO11, Purity: 99.9%)

High Purity Doxorubicin Hydrochloride

Product Doxorubicin Hydrochloride (C27H29NO11, Purity: 99.9%)

Quality Control: Each lot of Doxorubicin Hydrochloride was tested successfully.

SEM Analysis of Doxorubicin Hydrochloride

SEM Analysis of Doxorubicin Hydrochloride

Size Analysis of Doxorubicin Hydrochloride

Size Analysis of Doxorubicin Hydrochloride

 
Product Doxorubicin Hydrochloride
Stock No NS6130-12-000069
CAS 25316-40-9 Confirm
Purity 99.9% Confirm
Molecular Weight 810.3 g/mol Confirm
Boiling Point 2950 °C Confirm
Melting Point 216 ℃ Confirm
pH 4.5 – 5.0 Confirm
MF C27H29NO11 Confirm
Available Quantities 25Gms, 50Gms, 100Gms and larger quantities
Main Inspect Verifier Manager QC

Expert Reviews

Dr. Huojin Chan, (University of Science and Technology of China, Hefei, Anhui, China)

Doxorubicin Hydrochloride sold under the trade names Adriamycin among others, is a medication used in cancer chemotherapy. It is derived by chemical semisynthesis from a bacterial species. It is an anthracycline antitumor antibiotic (note: in this context, this does not mean it is used to treat bacterial infections) closely related to the natural product daunomycin and like all anthracyclines, it works by intercalating DNA, with the most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies (blood cancers, like leukaemia and lymphoma), many types of carcinoma (solid tumours) and soft tissue sarcomas. It is often used in combination chemotherapy as a component of various chemotherapy regimens.


Dr. Bruce Perrault, Ph.D, (Georgia Institute of Technology (Georgia Tech), USA)

Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.


Dr. Myron Rubenstein, Ph.D, (Polytechnic University of Turin, Italy)

Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.


Dr. Ms. Yi Yen Sh, (King Mongkut’s University of Technology Thonburi,Bangkok, Thailand)

Antimitotic and cytotoxic. Doxorubicin Hydrochloride has been used successfully to produce regression in a wide range of neoplastic conditions including acute leukaemia, lymphomas, soft-tissue and osteogenic sarcomas, paediatric malignancies and adult solid tumours; in particular breast and lung carcinomas. Doxorubicin is frequently used in combination chemotherapy regimens with other cytotoxic drugs. Doxorubicin cannot be used as an antibacterial agent.


Doxorubicin Hydrochloride

Doxorubicin Hydrochloride


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